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Article

Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness.

Oncogene - 7 Dec 2017

Hsu F-F, Chiang M-T, Li F-A, Yeh C-T, Lee W-H, Chau L-Y

Abstract excerpt

Overexpression of heme oxygenase-1 (HO-1), an endoplasmic reticulum-anchored enzyme, is observed in many cancers. HO-1 nuclear translocation has been shown to correlate with progression of several cancers. We recently reported that HO-1 is susceptible to intramembrane proteolysis and translocates to the nucleus to promote cancer growth and invasiveness without depending on its enzymatic activity. In the present...

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PMID: 28846111
DOI: 10.1038/onc.2017.294

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