Article
Zika structural genes determine the virulence of African and Asian lineages.
Emerging microbes & infections - 1 Dec 2020
Nunes Bruno T D, Fontes-Garfias Camila R, Shan Chao, Muruato Antonio E, Nunes Jannyce G C, Burbano Rommel M R, Vasconcelos Pedro F C, Shi Pei-Yong, Medeiros Daniele B A
Abstract excerpt
The Asian lineage of Zika virus (ZIKV) is responsible for the recent epidemics in the Americas and severe disease, whereas the African lineage of ZIKV has not been reported to cause epidemics or severe disease. We constructed a cDNA infectious clone (IC) of an African ZIKV strain, which, together with our previously developed Asian ZIKV strain IC, allowed us to engineer chimeric viruses by swapping the structural...
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