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Article

The distinguishing NS5-M114V mutation in American Zika virus isolates has negligible impacts on virus replication and transmission potential.

PLoS neglected tropical diseases - 1 May 2022

Peng Nias Y G, Amarilla Alberto A, Hugo Leon E, Modhiran Naphak, Sng Julian D J, Slonchak Andrii, Watterson Daniel, Setoh Yin Xiang, Khromykh Alexander A

Abstract excerpt

During 2015-2016, outbreaks of Zika virus (ZIKV) occurred in Southeast Asia and the Americas. Most ZIKV infections in humans are asymptomatic, while clinical manifestation is usually a self-limiting febrile disease with maculopapular rash. However, ZIKV is capable of inducing a range of severe neurological complications collectively described as congenital Zika syndrome (CZS). Notably, the scale and magnitude of...

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Identifiers

PMID: 35536870
DOI: 10.1371/journal.pntd.0010426
PMCID: PMC9122223

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