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Influence of Zika virus 3′-end sequence and nonstructural protein evolution on the viral replication competence and virulence

23 Sept 2022

Abstract excerpt

Zika virus (ZIKV) has been circulating in human networks over 70 years since its first appearance in Africa, yet little is known about whether the viral 3'-terminal sequence and nonstructural (NS) protein diverged genetically from ancient ZIKV have different effects on viral replication and virulence in currently prevailing Asian lineage ZIKV. Here we show, by a reverse genetics approach using an infectious cDNA...

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PMID: 36149812
DOI: 10.1080/22221751.2022.2128433

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