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Article

Leu-to-Phe substitution at prM146 decreases the growth ability of Zika virus and partially reduces its pathogenicity in mice.

Scientific reports - 4 Oct 2021

Inagaki Takuya, Taniguchi Satoshi, Kawai Yasuhiro, Maeki Takahiro, Nakayama Eri, Tajima Shigeru, Takeyama Haruko, Lim Chang Kweng, Saijo Masayuki

Abstract excerpt

Zika virus (ZIKV) is a mosquito-borne flavivirus that causes febrile illness. The recent spread of ZIKV from Asia to the Americas via the Pacific region has revealed unprecedented features of ZIKV, including transplacental congenital infection causing microcephaly. Amino acid changes have been hypothesized to underlie the spread and novel features of American ZIKV strains; however, the relationship between...

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Identifiers

PMID: 34608212
DOI: 10.1038/s41598-021-99086-2
PMCID: PMC8490429

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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