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Article

Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice

3 Jul 2017

Abstract excerpt

Zika virus (ZIKV) falls into two lineages: African (ZIKVAF) and Asian (ZIKVAS). These lineages have not been tested comprehensively in parallel for disease progression using an animal model system. Here, using the established type-I interferon receptor knockout (A129) mouse model, it is first demonstrated that ZIKVAF causes lethal infection, with different kinetics of disease manifestations according to the...

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PMID: 28672028
DOI: 10.1371/journal.pntd.0005704

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