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Article

DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression.

Science signaling - 17 Sept 2024

Afshar-Sterle Shoukat, Carli Annalisa L E, O'Keefe Ryan, Tse Janson, Fischer Stefanie, Azimpour Alexander I, Baloyan David, Elias Lena, Thilakasiri Pathum, Patel Onisha, Ferguson Fleur M, Eissmann Moritz F, Chand Ashwini L, Gray Nathanael S, Busuttil Rita, Boussioutas Alex, Lucet Isabelle S, Ernst Matthias, Buchert Michael

Abstract excerpt

Doublecortin-like kinase 1 (DCLK1) is a proposed driver of gastric cancer (GC) that phosphorylates serine and threonine residues. Here, we showed that the kinase activity of DCLK1 orchestrated cancer cell-intrinsic and-extrinsic processes that led to pro-invasive and pro-metastatic reprogramming of GC cells. Inhibition of the kinase activity of DCLK1 reduced the growth of subcutaneous xenograft tumors formed from...

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Identifiers

PMID: 39288218
DOI: 10.1126/scisignal.abq4888

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Related research

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DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression.PMID 39288218Read ↗

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