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Article

Protective association of the ε2/ε3 heterozygote with Alzheimer's disease is strengthened by TOMM40-APOE variants in men.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2021

Kulminski Alexander M, Philipp Ian, Loika Yury, He Liang, Culminskaya Irina

Abstract excerpt

INTRODUCTION: Despite advances, understanding the protective role of the apolipoprotein E (APOE) ε2 allele in Alzheimer's disease (AD) remains elusive. METHODS: We examined associations of variants comprised of the TOMM40 rs8106922 and APOE rs405509, rs440446, and ε2-encoding rs7412 polymorphisms with AD in a sample of 2862 AD-affected and 169,516 AD-unaffected non-carriers of the ε4 allele. RESULTS: Association...

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Share to Aged, 80 and over
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Share to Mitochondrial Precursor Protein Import Complex Proteins
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Source

Open in PubMed Open full text

Identifiers

PMID: 34310032
DOI: 10.1002/alz.12413
PMCID: PMC8648881

Genes

APOE
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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