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Article

ubtor Mutation Causes Motor Hyperactivity by Activating mTOR Signaling in Zebrafish.

Neuroscience bulletin - 1 Dec 2021

Wang Tiantian, Zhou Mingshan, Zhang Quan, Zhang Cuizhen, Peng Gang

Abstract excerpt

Mechanistic target of rapamycin (mTOR) signaling governs important physiological and pathological processes key to cellular life. Loss of mTOR negative regulators and subsequent over-activation of mTOR signaling are major causes underlying epileptic encephalopathy. Our previous studies showed that UBTOR/KIAA1024/MINAR1 acts as a negative regulator of mTOR signaling, but whether UBTOR plays a role in neurological...

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Identifiers

PMID: 34309811
DOI: 10.1007/s12264-021-00755-z
PMCID: PMC8643380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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