Article
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids.
Cell reports - 28 May 2024
Dhaliwal Navroop K, Weng Octavia Yifang, Dong Xiaoxue, Bhattacharya Afrin, Ahmed Mai, Nishimura Haruka, Choi Wendy W Y, Aggarwal Aditi, Luikart Bryan W, Shu Qiang, Li Xuekun, Wilson Michael D, Moffat Jason, Wang Lu-Yang, Muffat Julien, Li Yun
Abstract excerpt
Mutations in the phosphatase and tensin homolog (PTEN) gene are associated with severe neurodevelopmental disorders. Loss of PTEN leads to hyperactivation of the mechanistic target of rapamycin (mTOR), which functions in two distinct protein complexes, mTORC1 and mTORC2. The downstream signaling mechanisms that contribute to PTEN mutant phenotypes are not well delineated. Here, we show that pluripotent stem...
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