Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cells

26 Feb 2019

Abstract excerpt

Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolism. The importance of mTORC1 signaling in neuronal development and functions has been highlighted by its strong relationship with many neurological and neuropsychiatric diseases. Previous studies demonstrated that hyperactivation of mTORC1 in forebrain recapitulates tuberous sclerosis and neurodegeneration. In the mouse cerebellum,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PI3K/AKT/mTOR signaling in cancer
Share to Polyamine Metabolism and Applications
Share to Tuberous Sclerosis Complex Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30808980
DOI: 10.1038/s41598-019-38730-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hyperactivation of mTORC1 disrupts cellular homeostasis in cerebellar Purkinje cellsPMID 30808980Read ↗

Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice.Semantic proximity Read ↗

A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures.Semantic proximity Read ↗

Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism-like neurobehavioral phenotype in a rat model.Semantic proximity Read ↗

Revisiting Brain Tuberous Sclerosis Complex in Rat and Human: Shared Molecular and Cellular Pathology Leads to Distinct Neurophysiological and Behavioral Phenotypes.Semantic proximity Read ↗

Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology.Semantic proximity Read ↗

Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycinSemantic proximity Read ↗

Molecular neurobiology of mTORSemantic proximity Read ↗

Tsc1-mTOR signaling controls the structure and function of midbrain dopamine neuronsSemantic proximity Read ↗

Brain Symptoms of Tuberous Sclerosis Complex: Pathogenesis and Treatment.Semantic proximity Read ↗

mTOR signaling in epilepsy: insights from malformations of cortical development.Semantic proximity Read ↗

Complex Neurological Phenotype in Mutant Mice Lacking Tsc2 in Excitatory Neurons of the Developing Forebrain(123).Semantic proximity Read ↗

mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.