Article

Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity

2025-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Biallelic pathogenic variants in STRADA , an upstream regulator of the mechanistic target of rapamycin (mTOR) pathway, result in megalencephaly, drug-resistant epilepsy, and severe intellectual disability. This study explores how mTOR pathway hyperactivity alters cell fate specification in dorsal and ventral forebrain development using STRADA knock-out human stem cell derived brain organoids....

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Literature Corpus work: 79a9ca7f-730e-5bf7-8f0c-38930d7e8909
DOI: 10.1101/2025.05.13.653911

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