Article

Hyperactivity of mTORC1 and mTORC2-dependent signaling mediate epilepsy downstream of somatic PTEN loss

2023-08-19

Abstract excerpt

Gene variants that hyperactivate PI3K-mTOR signaling in the brain lead to epilepsy and cortical malformations in humans. Some gene variants associated with these pathologies only hyperactivate mTORC1, but others, such as PTEN , PIK3CA , and AKT , hyperactivate both mTORC1- and mTORC2-dependent signaling. Previous work established a key role for mTORC1 hyperactivity in mTORopathies, however, whether mTORC2 hyper...

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Literature Corpus work: 338cfd72-4fdd-50eb-99ec-079b550b1745
DOI: 10.1101/2023.08.18.553856

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