Article

Tanc2-dependent direct and regulated mTOR inhibition balances mTORC1/2 signaling in developing mouse and human neurons

2020-07-28

Abstract excerpt

<title>Abstract</title> <p>mTOR signaling, involving mTORC1 and mTORC2 complexes, critically regulates neural development and is implicated in various brain disorders. mTORC1/2 components that stimulate mTOR kinase activity strongly affect neurodevelopment, but mTOR-inhibitory mTORC1/2 components do not, questioning the role of balanced mTOR regulation in neurodevelopment. We found a direct, regulated inhibition...

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Literature Corpus work: 3e020006-9038-5aa6-9a63-8b18d3cf6819
DOI: 10.21203/rs.3.rs-40009/v1

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