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Article

Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif.

Acta crystallographica. Section D, Structural biology - 1 May 2018

Thompson Andrew J, Spears Richard J, Zhu Yanping, Suits Michael D L, Williams Spencer J, Gilbert Harry J, Davies Gideon J

Abstract excerpt

A dominant human gut microbe, the well studied symbiont Bacteroides thetaiotaomicron (Bt), is a glyco-specialist that harbors a large repertoire of genes devoted to carbohydrate processing. Despite strong similarities among them, many of the encoded enzymes have evolved distinct substrate specificities, and through the clustering of cognate genes within operons termed polysaccharide-utilization loci (PULs) enable...

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Identifiers

PMID: 29717710
DOI: 10.1107/S2059798318002942
PMCID: PMC5930347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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