Article

In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesis

2022-01-28

Abstract excerpt

<h4>ABSTRACT</h4> Human milk oligosaccharides (HMOs) form the third most abundant component of human milk and are known to convey several benefits to the neonate, including protection from viral and bacterial pathogens, training of the immune system, and influencing the gut microbiome. As HMO production during lactation is driven by enzymes that are common to other glycosylation processes, we adapted a model of m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 86de8ec3-230b-59b6-bc76-0c8e1ef8ece6
DOI: 10.1101/2022.01.27.477885

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

In silico analysis of the human milk oligosaccharide glycome reveals key enzymes of their biosynthesisDOI 10.1101/2022.01.27.477885Read

Elucidating Human Milk Oligosaccharide biosynthetic genes through network-based multiomics integrationSemantic proximity Read

Mammalian Milk Glycomes: Connecting the Dots between Evolutionary Conservation and Biosynthetic PathwaysSemantic proximity Read

Glycosyltransferases in human milk oligosaccharide synthesis: structural mechanisms and rational designSemantic proximity Read

Linking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyondSemantic proximity Read

Microbial Glycoside Hydrolases in the First Year of Life: An Analysis Review on Their Presence and Importance in Infant GutSemantic proximity Read

Integrated ‘omics analysis reveals human milk oligosaccharide biosynthesis programs in human lactocytesSemantic proximity Read

A unique role for Clostridium perfringens in the digestion of HMOsSemantic proximity Read

Identification of a novel Human Milk Oligosaccharides utilization cluster in the infant gut commensal Bacteroides doreiSemantic proximity Read

Utilization efficiency of human milk oligosaccharides by human-associated <i>Akkermansia</i> is strain-dependentSemantic proximity Read

Engineered Microbial Routes for Human Milk Oligosaccharides SynthesisSemantic proximity Read

Gold standard for nutrition: a review of human milk oligosaccharide and its effects on infant gut microbiotaSemantic proximity Read

A bifidobacterial enzyme orchestrates ecology and function of infant gut bacterial communitySemantic proximity Read