Article
Plasma Levels of Soluble Interleukin-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2015
Durda Peter, Sabourin Jeremy, Lange Ethan M, Nalls Mike A, Mychaleckyj Josyf C, Jenny Nancy Swords, Li Jin, Walston Jeremy, Harris Tamara B, Psaty Bruce M, Valdar William, Liu Yongmei, Cushman Mary, Reiner Alex P, Tracy Russell P, Lange Leslie A
Abstract excerpt
OBJECTIVE: Interleukin (IL) -2 receptor subunit α regulates lymphocyte activation, which plays an important role in atherosclerosis. Associations between soluble IL-2Rα (sIL-2Rα) and cardiovascular disease (CVD) have not been widely studied and little is known about the genetic determinants of sIL-2Rα levels. APPROACH AND RESULTS: We measured baseline levels of sIL-2Rα in 4408 European American (EA) and 766...
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