Article
RNase κ promotes robust piRNA production by generating 2',3'-cyclic phosphate-containing precursors.
Nature communications - 23 Jul 2021
Shigematsu Megumi, Kawamura Takuya, Morichika Keisuke, Izumi Natsuko, Kiuchi Takashi, Honda Shozo, Pliatsika Venetia, Matsubara Ryuma, Rigoutsos Isidore, Katsuma Susumu, Tomari Yukihide, Kirino Yohei
Abstract excerpt
In animal germlines, PIWI proteins and the associated PIWI-interacting RNAs (piRNAs) protect genome integrity by silencing transposons. Here we report the extensive sequence and quantitative correlations between 2',3'-cyclic phosphate-containing RNAs (cP-RNAs), identified using cP-RNA-seq, and piRNAs in the Bombyx germ cell line and mouse testes. The cP-RNAs containing 5'-phosphate (P-cP-RNAs) identified by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.