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Article

TGFβ-induced SMAD4-dependent Apoptosis Proceeded by EMT in CRC

3 May 2019

Abstract excerpt

Abstract Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. In Saudi Arabia, colorectal cancer is more aggressive and presents at younger age, warranting new treatment strategies. Role of TGFβ/Smad4 signaling pathway in initiation and progression of colorectal cancer is well documented. This study examined the role of TGFβ/Smad4 signaling pathway in a large cohort of Saudi patients...

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PMID: 31053577
DOI: 10.1158/1535-7163.mct-18-1378

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