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Article

Tumor Escape Phenotype in Bladder Cancer Is Associated with Loss of HLA Class I Expression, T-Cell Exclusion and Stromal Changes.

International journal of molecular sciences - 6 Jul 2021

Gil-Julio Hernani, Perea Francisco, Rodriguez-Nicolas Antonio, Cozar Jose Manuel, González-Ramirez Amanda Rocío, Concha Angel, Garrido Federico, Aptsiauri Natalia, Ruiz-Cabello Francisco

Abstract excerpt

Cancer eradication and clinical outcome of immunotherapy depend on tumor cell immunogenicity, including HLA class I (HLA-I) and PD-L1 expression on malignant cells, and on the characteristics of the tumor microenvironment, such as tumor immune infiltration and stromal reaction. Loss of tumor HLA-I is a common mechanism of immune escape from cytotoxic T lymphocytes and is linked to cancer progression and...

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Share to B7-H1 Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphocytes, Tumor-Infiltrating

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Source

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Identifiers

PMID: 34298868
DOI: 10.3390/ijms22147248
PMCID: PMC8307653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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