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Article

Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer.

Cancer immunology research - 1 Jul 2016

Sweis Randy F, Spranger Stefani, Bao Riyue, Paner Gladell P, Stadler Walter M, Steinberg Gary, Gajewski Thomas F

Abstract excerpt

Muscle-invasive urothelial bladder cancer is a common malignancy with poor outcomes for which immune checkpoint blockade is now showing promise. Despite clinical activity of PD-1/PD-L1-targeted therapy in this disease, most patients do not benefit and resistance mechanisms remain unknown. The non-T-cell-inflamed tumor microenvironment correlates with poor prognosis and resistance to immunotherapies. In this...

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Source

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Identifiers

PMID: 27197067
DOI: 10.1158/2326-6066.CIR-15-0274
PMCID: PMC4943758

Genes

FGFR3
FOXP3
LAG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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