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Article

Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination.

PLoS genetics - 1 Jul 2021

Su Jie, Xu Ran, Mongia Piyusha, Toyofuku Naoko, Nakagawa Takuro

Abstract excerpt

Gross chromosomal rearrangements (GCRs), including translocation, deletion, and inversion, can cause cell death and genetic diseases such as cancer in multicellular organisms. Rad51, a DNA strand exchange protein, suppresses GCRs by repairing spontaneous DNA damage through a conservative way of homologous recombination, gene conversion. On the other hand, Rad52 that catalyzes single-strand annealing (SSA) causes...

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Identifiers

PMID: 34292936
DOI: 10.1371/journal.pgen.1009671
PMCID: PMC8297803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination.PMID 34292936Read ↗

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Defects in DNA ligase I trigger PCNA ubiquitylation at Lys 107.Semantic proximity Read ↗

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Rad51 paralog complex Rad55–Rad57 acts as a molecular chaperone during homologous recombinationSemantic proximity Read ↗

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