Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rtt107 cooperates with Rad55 to limit specific types of genome instability in Saccharomyces cerevisiae.

DNA repair - 1 Jun 2026

Brown Joshua A R, Brewis Hilary T, Kobor Michael S

Abstract excerpt

A range of genome maintenance factors respond to endogenous and exogenous DNA damage to prevent mutations and cell death. The scaffold protein, Rtt107, is important for the growth of cells exposed to DNA-damaging agents in the budding yeast Saccharomyces cerevisiae. Rtt107 binds to a diverse array of partner proteins and responds to DNA damage by localizing to phosphorylated histone H2A. Rad55-Rad57, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Repair

Share to Genomic Instability

Share to Loss of Heterozygosity

Share to Nuclear Proteins

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 42139978
DOI: 10.1016/j.dnarep.2026.103937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rtt107 cooperates with Rad55 to limit specific types of genome instability in Saccharomyces cerevisiae.PMID 42139978Read ↗

DNA-repair scaffolds dampen checkpoint signalling by counteracting the adaptor Rad9.Semantic proximity Read ↗

Fission yeast Rad8/HLTF facilitates Rad52-dependent chromosomal rearrangements through PCNA lysine 107 ubiquitination.Semantic proximity Read ↗

Rtt107 BRCT domains act as a targeting module in the DNA damage response.Semantic proximity Read ↗

Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway.Semantic proximity Read ↗

Rtt107 Is a Multi-functional Scaffold Supporting Replication Progression with Partner SUMO and Ubiquitin Ligases.Semantic proximity Read ↗

Rtt107 is required for recruitment of the SMC5/6 complex to DNA double strand breaks.Semantic proximity Read ↗

A mutant allele of the transcription factor IIH helicase gene, RAD3, promotes loss of heterozygosity in response to a DNA replication defect in Saccharomyces cerevisiae.Semantic proximity Read ↗

High-resolution genome-wide analysis of irradiated (UV and γ-rays) diploid yeast cells reveals a high frequency of genomic loss of heterozygosity (LOH) events.Semantic proximity Read ↗

Role of the Saccharomyces cerevisiae Rad51 paralogs in sister chromatid recombination.Semantic proximity Read ↗

The Ddc1-Mec3-Rad17 sliding clamp regulates histone-histone chaperone interactions and DNA replication-coupled nucleosome assembly in budding yeast.Semantic proximity Read ↗

The Role of the Rad55-Rad57 Complex in DNA Repair.Semantic proximity Read ↗

A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.