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Associated Genetics and Connectomic Circuitry in Schizophrenia and Bipolar Disorder.

Biological psychiatry - 15 Jul 2023

Wei Yongbin, de Lange Siemon C, Savage Jeanne E, Tissink Elleke, Qi Ting, Repple Jonathan, Gruber Marius, Kircher Tilo, Dannlowski Udo, Posthuma Danielle, van den Heuvel Martijn P

Abstract excerpt

BACKGROUND: Schizophrenia (SCZ) and bipolar disorder (BD) are severe psychiatric conditions that can involve symptoms of psychosis and cognitive dysfunction. The 2 conditions share symptomatology and genetic etiology and are regularly hypothesized to share underlying neuropathology. Here, we examined how genetic liability to SCZ and BD shapes normative variations in brain connectivity. METHODS: We examined the...

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PMID: 36803976
DOI: 10.1016/j.biopsych.2022.11.006

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