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Article

Contributions of HFE polymorphisms to brain and blood iron load, and their links to cognitive and motor function in healthy adults.

Neuropsychopharmacology reports - 1 Sept 2021

Kalpouzos Grégoria, Mangialasche Francesca, Falahati Farshad, Laukka Erika J, Papenberg Goran

Abstract excerpt

BACKGROUND: Brain iron overload is linked to brain deterioration, and cognitive and motor impairment in neurodegenerative disorders and normal aging. Mutations in the HFE gene are associated with iron dyshomeostasis and are risk factors for peripheral iron overload. However, links to brain iron load and cognition are less consistent and data are scarce. AIMS AND METHODS: Using quantitative susceptibility mapping...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34291615
DOI: 10.1002/npr2.12197
PMCID: PMC8411306

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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