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Detection of cell‐free DNA fragmentation and copy number alterations in cerebrospinal fluid from glioma patients

6 Nov 2018

Abstract excerpt

Glioma is difficult to detect or characterize using current liquid biopsy approaches. Detection of cell‐free tumor DNA (cftDNA) in cerebrospinal fluid (CSF) has been proposed as an alternative to detection in plasma. We used shallow whole‐genome sequencing (sWGS, at a coverage of < 0.4×) of cell‐free DNA from the CSF of 13 patients with primary glioma to determine somatic copy number alterations and DNA...

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PMID: 30401727
DOI: 10.15252/emmm.201809323

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