Cerebrospinal Fluid cfDNA Sequencing for Classification of Central Nervous System Glioma.

doi:10.1158/1078-0432.CCR-23-2907

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Article

Cerebrospinal Fluid cfDNA Sequencing for Classification of Central Nervous System Glioma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2024

Iser Florian, Hinz Felix, Hoffmann Dirk C, Grassl Niklas, Güngoör Cansu, Meyer Jochen, Dörner Laura, Hofmann Lea, Kelbch Vanessa, Göbel Kirsten, Mahmutoglu Mustafa Ahmed, Vollmuth Philipp, Patel Areeba, Nguyen Duy, Kaulen Leon D, Mildenberger Iris, Sahm Katharina, Maaß Kendra, Pajtler Kristian W, Shankar Ganesh M, Weiler Markus, Wildemann Brigitte, Winkler Frank, von Deimling Andreas, Platten Michael, Wick Wolfgang, Sahm Felix, Kessler Tobias

Abstract excerpt

PURPOSE: Primary central nervous system (CNS) gliomas can be classified by characteristic genetic alterations. In addition to solid tissue obtained via surgery or biopsy, cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) is an alternative source of material for genomic analyses. EXPERIMENTAL DESIGN: We performed targeted next-generation sequencing of CSF cfDNA in a representative cohort of 85 patients...

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PMID: 38295147
DOI: 10.1158/1078-0432.CCR-23-2907
PMCID: PMC11247324

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