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CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1

21 Jul 2021

Abstract excerpt

More than 70% of colorectal, prostate, ovarian, pancreatic and breast cancer specimens show expression of CD276 (B7-H3), a potential immune checkpoint family member. Several studies have shown that high CD276 expression in cancer cells correlates with a poor clinical prognosis. This has been associated with the presence of lower tumor infiltrating leukocytes. Among those, tumor-associated macrophages can comprise...

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PMID: 34290311
DOI: 10.1038/s41598-021-94360-9

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