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Article

Price equation captures the role of drug interactions and collateral effects in the evolution of multidrug resistance.

eLife - 22 Jul 2021

Gjini Erida, Wood Kevin B

Abstract excerpt

Bacterial adaptation to antibiotic combinations depends on the joint inhibitory effects of the two drugs (drug interaction [DI]) and how resistance to one drug impacts resistance to the other (collateral effects [CE]). Here we model these evolutionary dynamics on two-dimensional phenotype spaces that leverage scaling relations between the drug-response surfaces of drug-sensitive (ancestral) and drug-resistant...

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Identifiers

PMID: 34289932
DOI: 10.7554/eLife.64851
PMCID: PMC8331190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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