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Article

Microvesicles carrying LRP5 induce macrophage polarization to an anti-inflammatory phenotype.

Journal of cellular and molecular medicine - 1 Aug 2021

Luquero Aureli, Vilahur Gemma, Crespo Javier, Badimon Lina, Borrell-Pages Maria

Abstract excerpt

Microvesicles (MV) contribute to cell-to-cell communication through their transported proteins and nucleic acids. MV, released into the extracellular space, exert paracrine regulation by modulating cellular responses after interaction with near and far target cells. MV are released at high concentrations by activated inflammatory cells. Different subtypes of human macrophages have been characterized based on...

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Identifiers

PMID: 34288375
DOI: 10.1111/jcmm.16723
PMCID: PMC8358886

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