Article
Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22.
Frontiers in immunology - 1 Jan 2018
Hyvärinen Kati, Holopainen Minna, Skirdenko Vita, Ruhanen Hanna, Lehenkari Petri, Korhonen Matti, Käkelä Reijo, Laitinen Saara, Kerkelä Erja
Abstract excerpt
Resolution-phase macrophage population orchestrates active dampening of the inflammation by secreting anti-inflammatory and proresolving products including interleukin (IL)-10 and lipid mediators (LMs). We investigated the effects of both human bone marrow-derived mesenchymal stromal cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) on mature human regulatory macrophages (Mregs). The cytokines and LMs...
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