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Article

Development of antibacterial compounds that constrain evolutionary pathways to resistance.

eLife - 19 Jul 2021

Zhang Yanmin, Chowdhury Sourav, Rodrigues João V, Shakhnovich Eugene

Abstract excerpt

Antibiotic resistance is a worldwide challenge. A potential approach to block resistance is to simultaneously inhibit WT and known escape variants of the target bacterial protein. Here, we applied an integrated computational and experimental approach to discover compounds that inhibit both WT and trimethoprim (TMP) resistant mutants of E. coli dihydrofolate reductase (DHFR). We identified a novel compound...

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Identifiers

PMID: 34279221
DOI: 10.7554/eLife.64518
PMCID: PMC8331180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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