Article
A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.
Genes and immunity - 1 Jul 2012
Wang S, Adrianto I, Wiley G B, Lessard C J, Kelly J A, Adler A J, Glenn S B, Williams A H, Ziegler J T, Comeau M E, Marion M C, Wakeland B E, Liang C, Kaufman K M, Guthridge J M, Alarcón-Riquelme M E, Alarcón G S, Anaya J-M, Bae S-C, Kim J-H, Joo Y B, Boackle S A, Brown E E, Petri M A, Ramsey-Goldman R, Reveille J D, Vilá L M, Criswell L A, Edberg J C, Freedman B I, Gilkeson G S, Jacob C O, James J A, Kamen D L, Kimberly R P, Martin J, Merrill J T, Niewold T B, Pons-Estel B A, Scofield R H, Stevens A M, Tsao B P, Vyse T J, Langefeld C D, Harley J B, Wakeland E K, Moser K L, Montgomery C G, Gaffney P M
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations characterized by the development of pathogenic autoantibodies manifesting in inflammation of target organs such as the kidneys, skin and joints. Genome-wide association studies have identified genetic variants in the UBE2L3 region that are associated with SLE in subjects of European and Asian ancestry. UBE2L3 encodes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.