UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.

doi:10.1016/j.ajhg.2014.12.024

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Article

UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.

American journal of human genetics - 5 Feb 2015

Lewis Myles J, Vyse Simon, Shields Adrian M, Boeltz Sebastian, Gordon Patrick A, Spector Timothy D, Lehner Paul J, Walczak Henning, Vyse Timothy J

Abstract excerpt

UBE2L3 is associated with increased susceptibility to numerous autoimmune diseases, but the underlying mechanism is unexplained. By using data from a genome-wide association study of systemic lupus erythematosus (SLE), we observed a single risk haplotype spanning UBE2L3, consistently aligned across multiple autoimmune diseases, associated with increased UBE2L3 expression in B cells and monocytes. rs140490 in the...

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PMID: 25640675
DOI: 10.1016/j.ajhg.2014.12.024
PMCID: PMC4320258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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