Article
A regulatory variant at 19p13.3 is associated with primary biliary cholangitis risk and ARID3A expression.
Nature communications - 28 Mar 2023
Li You, Li Zhiqiang, Chen Ruiling, Lian Min, Wang Hanxiao, Wei Yiran, You Zhengrui, Zhang Jun, Li Bo, Li Yikang, Huang Bingyuan, Chen Yong, Liu Qiaoyan, Lyu Zhuwan, Liang Xueying, Miao Qi, Xiao Xiao, Wang Qixia, Fang Jingyuan, Shi YongYong, Liu Xiangdong, Seldin Michael F, Gershwin M Eric, Tang Ruqi, Ma Xiong
Abstract excerpt
Genome-wide association studies have identified 19p13.3 locus associated with primary biliary cholangitis (PBC). Here we aim to identify causative variant(s) and initiate efforts to define the mechanism by which the 19p13.3 locus variant(s) contributes to the pathogenesis of PBC. A genome-wide meta-analysis of 1931 PBC subjects and 7852 controls in two Han Chinese cohorts confirms the strong association between...
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