Article
Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.
Cancer discovery - 1 Apr 2014
Yang Yibin, Schmitz Roland, Mitala Joseph, Whiting Amanda, Xiao Wenming, Ceribelli Michele, Wright George W, Zhao Hong, Yang Yandan, Xu Weihong, Rosenwald Andreas, Ott German, Gascoyne Randy D, Connors Joseph M, Rimsza Lisa M, Campo Elias, Jaffe Elaine S, Delabie Jan, Smeland Erlend B, Braziel Rita M, Tubbs Raymond R, Cook James R, Weisenburger Dennis D, Chan Wing C, Wiestner Adrian, Kruhlak Michael J, Iwai Kazuhiro, Bernal Federico, Staudt Louis M
Abstract excerpt
UNLABELLED: Constitutive activation of NF-κB is a hallmark of the activated B cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), owing to upstream signals from the B-cell receptor (BCR) and MYD88 pathways. The linear polyubiquitin chain assembly complex (LUBAC) attaches linear polyubiquitin chains to IκB kinase-γ, a necessary event in some pathways that engage NF-κB. Two germline polymorphisms...
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