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Article

Risk SNP-Mediated Enhancer-Promoter Interaction Drives Colorectal Cancer through Both FADS2 and AP002754.2.

Cancer research - 1 May 2020

Tian Jianbo, Lou Jiao, Cai Yimin, Rao Meilin, Lu Zequn, Zhu Ying, Zou Danyi, Peng Xiating, Wang Haoxue, Zhang Ming, Niu Siyuan, Li Yue, Zhong Rong, Chang Jiang, Miao Xiaoping

Abstract excerpt

Although genome-wide association studies (GWAS) have identified more than 100 colorectal cancer risk loci, most of the biological mechanisms associated with these loci remain unclear. Here we first performed a comprehensive expression quantitative trait loci analysis in colorectal cancer tissues adjusted for multiple confounders to test the determinants of germline variants in established GWAS susceptibility loci...

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PMID: 32127356
DOI: 10.1158/0008-5472.CAN-19-2389

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