Article
HSPA12A was identified as a key driver in colorectal cancer GWAS loci 10q26.12 and modulated by an enhancer-promoter interaction.
Archives of toxicology - 1 Jul 2023
Lu Zequn, Fan Linyun, Zhang Fuwei, Huang Chaoqun, Cai Yimin, Chen Can, Li Gaoyuan, Zhang Ming, Huang Jinyu, Ning Caibo, Li Yanmin, Wang Wenzhuo, Geng Hui, Liu Yizhuo, Chen Shuoni, Li Hanting, Yang Shuhui, Zhang Heng, Tian Wen, Ye Tianrun, Liu Jiuyang, Yang Xiaojun, Xu Bin, Zhu Ying, Zhong Rong, Li Heng, Tian Jianbo, Li Bin, Miao Xiaoping
Abstract excerpt
Although genome-wide association studies (GWASs) have identified over 100 colorectal cancer (CRC) risk loci, an understanding of causal genes or risk variants and their biological functions in these loci remain unclear. Recently, genomic loci 10q26.12 with lead SNP rs1665650 was identified as an essential CRC risk loci of Asian populations. However, the functional mechanism of this region has not been fully...
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