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Article

Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.

The Journal of biological chemistry - 1 Aug 2021

Xu Yuqun, Guo Chen, Pan Wenfei, Zhao Chan, Ding Yanyan, Xie Xingqiao, Wei Zhiyi, Sun Ying, Yu Cong

Abstract excerpt

Nephrotic syndrome (NS) is a common kidney disorder caused by dysfunction of the glomerular filtration barrier. Some genetic mutations identified in NS patients cause amino acid substitutions of kidney ankyrin repeat-containing (KANK) proteins, which are scaffold proteins that regulate actin polymerization, microtubule targeting, and cell adhesion via binding to various molecules, including the kinesin motor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34274317
DOI: 10.1016/j.jbc.2021.100958
PMCID: PMC8368038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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