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Article

Dysregulated Dynein-Mediated Trafficking of Nephrin Causes INF2-related Podocytopathy.

Journal of the American Society of Nephrology : JASN - 1 Feb 2021

Sun Hua, Perez-Gill Chandra, Schlöndorff Johannes S, Subramanian Balajikarthick, Pollak Martin R

Abstract excerpt

BACKGROUND: FSGS caused by mutations in INF2 is characterized by a podocytopathy with mistrafficked nephrin, an essential component of the slit diaphragm. Because INF2 is a formin-type actin nucleator, research has focused on its actin-regulating function, providing an important but incomplete insight into how these mutations lead to podocytopathy. A yeast two-hybridization screen identified the interaction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33443052
DOI: 10.1681/ASN.2020081109
PMCID: PMC8054882

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