Article
Neph1 Cooperates with Nephrin To Transduce a Signal That Induces Actin Polymerization
9 Oct 2007
Abstract excerpt
While the mechanisms that regulate actin dynamics in cellular motility are intensively studied, relatively little is known about signaling events that transmit outside-in signals and direct assembly and regulation of actin polymerization complexes at the cell membrane. The kidney podocyte provides a unique model for investigating these mechanisms since deletion of Nephrin or Neph1, two interacting components of...
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