Article
MAGI-2 and scaffold proteins in glomerulopathy.
American journal of physiology. Renal physiology - 1 Nov 2018
Empitu Maulana A, Kadariswantiningsih Ika N, Aizawa Masashi, Asanuma Katsuhiko
Abstract excerpt
In many cells and tissues, including the glomerular filtration barrier, scaffold proteins are critical in optimizing signal transduction by enhancing structural stability and functionality of their ligands. Recently, mutations in scaffold protein membrane-associated guanylate kinase inverted 2 (MAGI-2) encoding gene were identified among the etiology of steroid-resistant nephrotic syndrome. MAGI-2 interacts with...
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