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Article

Tumor microenvironment-adjusted prognostic implications of the KRAS mutation subtype in patients with stage III colorectal cancer treated with adjuvant FOLFOX.

Scientific reports - 16 Jul 2021

Park Hye Eun, Yoo Seung-Yeon, Cho Nam-Yun, Bae Jeong Mo, Han Sae-Won, Lee Hye Seung, Park Kyu Joo, Kim Tae-You, Kang Gyeong Hoon

Abstract excerpt

Several studies have reported that the prognostic effect of KRAS mutations on colorectal cancers (CRCs) varies depending on the type of mutation. Considering the effect of KRAS mutations on tumor microenvironment, we analyzed the prognostic significance of KRAS mutation types after adjusting for the tumor-infiltrating lymphocytes (TIL) and tumor-stromal percentage (TSP) statuses. In two independent cohorts, KRAS...

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Identifiers

PMID: 34272423
DOI: 10.1038/s41598-021-94044-4
PMCID: PMC8285533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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