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Analysis of the immune microenvironment in colorectal cancer with different KRAS gene subtypes

4 Aug 2025

Abstract excerpt

BACKGROUND: To explore the differences in tumor immune microenvironment between different KRAS mutation subtypes, and to provide a new direction for clinical immunotherapy of different subtypes of colorectal cancer. METHODS: We examined the spatial distribution of common inflammatory cell markers of CD8 + T cells, CD4 + T cells, natural killer cells, and B cells and macrophages in 55 colorectal cancer patients...

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PMID: 40759935
DOI: 10.1186/s12885-025-14660-5

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