Article
The prognostic value of KRAS mutations in patients with colorectal cancer.
Oncology reports - 1 Nov 2012
Inoue Yasuhiro, Saigusa Susumu, Iwata Takashi, Okugawa Yoshinaga, Toiyama Yuji, Tanaka Koji, Uchida Keiichi, Mohri Yasuhiko, Kusunoki Masato
Abstract excerpt
Our aim was to evaluate the KRAS genotypes of Japanese colorectal cancer (CRC) patients and to assess the effect of these genotypes on clinical outcome. A total of 99 patients with stage I-IV CRC who underwent resection were prospectively studied for KRAS mutations by direct sequencing. KRAS mutations were found in 37 (37.4%) of 99 patients. Of these, 11.1% were the KRAS p.G13D mutation and the remaining 26.2%...
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