Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.

doi:10.1038/s41467-021-24491-0

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Article

Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.

Nature communications - 16 Jul 2021

Stanzick Kira J, Li Yong, Schlosser Pascal, Gorski Mathias, Wuttke Matthias, Thomas Laurent F, Rasheed Humaira, Rowan Bryce X, Graham Sarah E, Vanderweff Brett R, Patil Snehal B, Robinson-Cohen Cassiane, Gaziano John M, O'Donnell Christopher J, Willer Cristen J, Hallan Stein, Åsvold Bjørn Olav, Gessner Andre, Hung Adriana M, Pattaro Cristian, Köttgen Anna, Stark Klaus J, Heid Iris M, Winkler Thomas W

Abstract excerpt

Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging. By GWAS meta-analysis for creatinine-based estimated glomerular filtration rate (eGFR) from the Chronic Kidney Disease Genetics Consortium and UK Biobank (n = 1,201,909), we expand the number of eGFRcrea loci (424 loci, 201...

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PMID: 34272381
DOI: 10.1038/s41467-021-24491-0
PMCID: PMC8285412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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