Article
PNPLA3 is the dominant SNP linked to liver disease severity at time of first referral to a tertiary center.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Jan 2022
Balcar Lorenz, Semmler Georg, Oberkofler Hannes, Zandanell Stephan, Strasser Michael, Datz Leonora, Niederseer David, Feldman Alexandra, Stickel Felix, Datz Christian, Paulweber Bernhard, Aigner Elmar
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) in genes including PNPLA3, TM6SF2, HSD17B13 and SERPINA1 have been identified as risk modifiers of progression in chronic liver disease (CLD). However, it is unclear whether genotyping for these risk variants is useful in clinical routine. METHODS: Liver disease severity was assessed by liver stiffness measurement (LSM) and by presence of clinical manifestations...
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