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Article

Genetic and non-genetic drivers of histological progression and regression in MASLD.

Journal of hepatology - 1 Mar 2026

Vilar-Gomez Eduardo, Yates Katherine P, Kleiner David E, Behling Cynthia, Cummings Oscar W, Wilson Laura A, Liang Tiebing, Jarasvaraparn Chaowapong, Loomba Rohit, Schwimmer Jeffrey B, Sanyal Arun J, Hoofnagle Jay, Chalasani Naga

Abstract excerpt

BACKGROUND & AIMS: The association between genetic variants and longitudinal changes in liver histology has not been well characterized. We examined relationships between three single nucleotide polymorphisms (SNPs) - PNPLA3 rs738409, TM6SF2 rs58542926, and HSD17B13 rs72613567 - and longitudinal changes in liver histology. METHODS: A total of 671 (444 adults and 227 children) individuals enrolled in different...

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Source

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Identifiers

PMID: 40998180
DOI: 10.1016/j.jhep.2025.09.013
PMCID: PMC12495455

Genes

HSD17B13
PNPLA3
TM6SF2
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

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Genetic and non-genetic drivers of histological progression and regression in MASLD.PMID 40998180Read ↗

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