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Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

14 Jul 2021

Abstract excerpt

Monoclonal antibodies, antibody fragments and fusion proteins derived thereof have revolutionized the practice of medicine. Major challenges faced by the biopharmaceutical industry are however high production costs, long processing times and low productivities associated with their production in mammalian cell lines. The yeast Saccharomyces cerevisiae, a well-characterized eukaryotic cell factory possessing the...

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PMID: 34261490
DOI: 10.1186/s12934-021-01624-0

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