Functional production of human antibody by the filamentous fungus Aspergillus oryzae

Abstract excerpt

<title>Abstract</title> <p>Background: Monoclonal antibodies (mAbs) as biopharmaceuticals take a pivotal role in the current therapeutic applications. Generally mammalian cell lines, such as those derived from Chinese hamster ovaries (CHO), are used to produce the recombinant antibody. However, there are still concerns about the high cost and the risk of pathogenic contamination when using mammalian cells. <itali...

Topics

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• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Enzyme Stability
• Escherichia coli
• Monoclonal and Polyclonal Antibodies Research
• Toxin Mechanisms and Immunotoxins
• Transgenic Plants and Applications
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

234207ef-5fc2-5805-a9c9-91f8155442a5

DOI

10.21203/rs.2.23960/v2